Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV-C/H2O2 and UV-C/S2O82- processes: Modeling, treatment optimization and biodegradability enhancement

Amin Samzadeh; Mansooreh Dehghani; Mohammad Ali Baghapour; Abooalfazl Azhdarpoor; Zahra Derakhshan; Matija Cvetnić; Tomislav Bolanča; Stefanos Giannakis; Ying Cao

doi:10.1016/j.envres.2022.113385

Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV-C/H₂O₂ and UV-C/S₂O₈^2- processes: Modeling, treatment optimization and biodegradability enhancement

Environ Res. 2022 Sep;212(Pt D):113385. doi: 10.1016/j.envres.2022.113385. Epub 2022 May 13.

Authors

Amin Samzadeh¹, Mansooreh Dehghani², Mohammad Ali Baghapour¹, Abooalfazl Azhdarpoor¹, Zahra Derakhshan³, Matija Cvetnić⁴, Tomislav Bolanča⁵, Stefanos Giannakis⁶, Ying Cao⁷

Affiliations

¹ Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
² Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran; Research Center for Health Sciences, Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mdehghany@sums.ac.ir.
³ Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran; Research Center for Health Sciences, Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev Trg 19, 10000, Zagreb, Croatia.
⁵ University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev Trg 19, 10000, Zagreb, Croatia; University North, Trg Dr. Žarka Dolinara 1, Koprivnica, 48000, Croatia.
⁶ Universidad Politécnica de Madrid, E.T.S. Ingenieros de Caminos, Canales y Puertos, Departamento de Ingeniería Civil: Hidráulica, Energía y Medio Ambiente, Unidad docente Ingeniería Sanitaria, c/ Profesor Aranguren, s/n, ES-28040, Madrid, Spain.
⁷ Universidad Politécnica de Madrid, E.T.S. Ingenieros de Caminos, Canales y Puertos, Departamento de Ingeniería Civil: Hidráulica, Energía y Medio Ambiente, Unidad docente Ingeniería Sanitaria, c/ Profesor Aranguren, s/n, ES-28040, Madrid, Spain; State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China. Electronic address: 18b929022@stu.hit.edu.cn.

PMID: 35569533
DOI: 10.1016/j.envres.2022.113385

Abstract

The pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO₄°^- based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling (RSM) was used to investigate the degradation of three typical pharmaceuticals (i.e., etodolac (ETD), febuxostat (FBU) and imatinib mesylate (IMT)) by UV/H₂O₂ and UV/S₂O₈^2- processes. Based on the multiple regression analysis on full factorial design matrix and calculated reaction rate constants, the RSM was built. The experimental rate constants under optimal conditions were quite close to those obtained from the model, implying the good fit of the RSM. In addition, the RSM results indicated that UV/S₂O₈^2- process was less sensitive to pH in comparison to the UV/H₂O₂ process on target contaminant removal. Finally, it showed that UV/S₂O₈^2- process was superior to the UV/H₂O₂ process to on the enhancement of target contaminant biodegradability.

Keywords: Biodegradability; Pharmaceuticals; Photo-oxidation; Response surface modeling (RSM).

MeSH terms

Etodolac
Febuxostat
Hydrogen Peroxide
Imatinib Mesylate
Oxidation-Reduction
Oxidative Stress
Ultraviolet Rays
Water Pollutants, Chemical* / analysis
Water Purification* / methods

Substances

Water Pollutants, Chemical
Febuxostat
Etodolac
Imatinib Mesylate
Hydrogen Peroxide