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. 2022 Apr 27:13:868751.
doi: 10.3389/fpsyt.2022.868751. eCollection 2022.

Cariprazine's Potential in Improving Social Dysfunction in Patients With Schizophrenia: A Perspective

Petr Morozov  1 , Roman Bekker  2 , Youri Bykov  3
Affiliations
Free PMC article

Cariprazine's Potential in Improving Social Dysfunction in Patients With Schizophrenia: A Perspective

Petr Morozov et al. Front Psychiatry. .
Free PMC article

Abstract

Social dysfunction is one of the most debilitating aspects of schizophrenia. Treatment of this complex phenomenon, constituted by negative, cognitive, and affective symptoms, has been difficult with the available pharmacological agents, hence it represents an unmet medical need. Cariprazine, a novel, third-generation antipsychotic with a unique mechanism of action has been proven to sufficiently alleviate negative, cognitive, and affective symptoms of schizophrenia. These characteristics make this compound a valid candidate for addressing social dysfunction too. In this perspective, we argue that cariprazine can be viewed as a "socializing drug" that has the ability to improve the patient's functionality and ultimately their quality of life. Data from animal research, clinical trials, an observational study, and patient cases are provided.

Keywords: D3 receptors; antipsychotic; cariprazine; schizophrenia; social dysfunction.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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