Are platelet indices promising ratios for predicting pediatric septic shock prognosis?

Bratisl Lek Listy. 2022;123(6):444-448. doi: 10.4149/BLL_2022_069.


Objectives: The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock.

Background: Septic shock is one of the major causes of mortality among children worldwide.

Methods: A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality.

Results: MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25-43.7; p=0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13-7.50; p=0.027) were significant risk factors for mortality.

Conclusions: Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).

Keywords: mortality; platelet indices; septic shock; thrombocytopenia children..

MeSH terms

  • Blood Platelets
  • Child
  • Humans
  • Mean Platelet Volume
  • Platelet Count
  • Prognosis
  • Retrospective Studies
  • Shock, Septic* / diagnosis