Bioavailable testosterone level is associated with COVID-19 severity in female: A sex-stratified Mendelian randomization study

doi:10.1016/j.jinf.2022.05.008

Comment

. 2022 Aug;85(2):174-211.

doi: 10.1016/j.jinf.2022.05.008. Epub 2022 May 14.

Bioavailable testosterone level is associated with COVID-19 severity in female: A sex-stratified Mendelian randomization study

Luna Liu¹, Xiude Fan², Qingbo Guan³, Chunxiao Yu⁴

Affiliations

¹ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China.
² Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
³ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. Electronic address: doctorguanqingbo@163.com.
⁴ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. Electronic address: yuchx08@163.com.

PMID: 35577073
PMCID: PMC9106418
DOI: 10.1016/j.jinf.2022.05.008

Comment

Bioavailable testosterone level is associated with COVID-19 severity in female: A sex-stratified Mendelian randomization study

Luna Liu et al. J Infect. 2022 Aug.

. 2022 Aug;85(2):174-211.

doi: 10.1016/j.jinf.2022.05.008. Epub 2022 May 14.

Authors

Luna Liu¹, Xiude Fan², Qingbo Guan³, Chunxiao Yu⁴

Affiliations

¹ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China.
² Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
³ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. Electronic address: doctorguanqingbo@163.com.
⁴ Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China; Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. Electronic address: yuchx08@163.com.

PMID: 35577073
PMCID: PMC9106418
DOI: 10.1016/j.jinf.2022.05.008

No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there is no conflict of interest.

Figures

**Fig. 1**
The Mendelian randomization analysis of casual effect between sex hormones and COVID-19 outcomes in females. IVW: inverse variance weighted; BAT: bioavailable testosterone; TT: total testosterone; SHBG: sex hormone binding globulin.

**Fig. 2**
The Mendelian randomization analysis of casual effect between sex hormones and COVID-19 outcomes in males. IVW: inverse variance weighted; BAT: bioavailable testosterone; TT: total testosterone; SHBG: sex hormone binding globulin.

See this image and copyright information in PMC

Comment on

Sex differences in mortality in the intensive care unit patients with severe COVID-19.
Moiseev S, Brovko M, Tao E, Bulanov N, Akulkina L, Fomin V. Moiseev S, et al. J Infect. 2021 Feb;82(2):282-327. doi: 10.1016/j.jinf.2020.09.031. Epub 2020 Sep 28. J Infect. 2021. PMID: 32998037 Free PMC article. No abstract available.

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References

1. Moiseev S., Brovko M., Tao E., Bulanov N., Akulkina L., Fomin V. Sex differences in mortality in the intensive care unit patients with severe COVID-19. J Infect. 2021;82(2):282–327. doi: 10.1016/j.jinf.2020.09.031. - DOI - PMC - PubMed
1. Ruth K.S., Day F.R., Tyrrell J., et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med. 2020;26(2):252–258. doi: 10.1038/s41591-020-0751-5. - DOI - PMC - PubMed
1. Wang Y., Guo P., Liu L., Zhang Y., Zeng P., Yuan Z. Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles. Endocrinology. 2021;162(5) doi: 10.1210/endocr/bqab037. bqab037. - DOI - PubMed
1. de Lusignan S., Joy M., Oke J., et al. Disparities in the excess risk of mortality in the first wave of COVID-19: cross sectional study of the English sentinel network. J Infect. 2020;81(5):785–792. doi: 10.1016/j.jinf.2020.08.037. - DOI - PMC - PubMed
1. Giefing-Kröll C., Berger P., Lepperdinger G., Grubeck-Loebenstein B. How sex and age affect immune responses, susceptibility to infections, and response to vaccination. Aging Cell. 2015;14(3):309–321. doi: 10.1111/acel.12326. - DOI - PMC - PubMed

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[1] Moiseev S., Brovko M., Tao E., Bulanov N., Akulkina L., Fomin V. Sex differences in mortality in the intensive care unit patients with severe COVID-19. J Infect. 2021;82(2):282–327. doi: 10.1016/j.jinf.2020.09.031. - DOI - PMC - PubMed

[2] Moiseev S., Brovko M., Tao E., Bulanov N., Akulkina L., Fomin V. Sex differences in mortality in the intensive care unit patients with severe COVID-19. J Infect. 2021;82(2):282–327. doi: 10.1016/j.jinf.2020.09.031. - DOI - PMC - PubMed

[3] Ruth K.S., Day F.R., Tyrrell J., et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med. 2020;26(2):252–258. doi: 10.1038/s41591-020-0751-5. - DOI - PMC - PubMed

[4] Ruth K.S., Day F.R., Tyrrell J., et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med. 2020;26(2):252–258. doi: 10.1038/s41591-020-0751-5. - DOI - PMC - PubMed

[5] Wang Y., Guo P., Liu L., Zhang Y., Zeng P., Yuan Z. Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles. Endocrinology. 2021;162(5) doi: 10.1210/endocr/bqab037. bqab037. - DOI - PubMed

[6] Wang Y., Guo P., Liu L., Zhang Y., Zeng P., Yuan Z. Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles. Endocrinology. 2021;162(5) doi: 10.1210/endocr/bqab037. bqab037. - DOI - PubMed

[7] de Lusignan S., Joy M., Oke J., et al. Disparities in the excess risk of mortality in the first wave of COVID-19: cross sectional study of the English sentinel network. J Infect. 2020;81(5):785–792. doi: 10.1016/j.jinf.2020.08.037. - DOI - PMC - PubMed

[8] de Lusignan S., Joy M., Oke J., et al. Disparities in the excess risk of mortality in the first wave of COVID-19: cross sectional study of the English sentinel network. J Infect. 2020;81(5):785–792. doi: 10.1016/j.jinf.2020.08.037. - DOI - PMC - PubMed

[9] Giefing-Kröll C., Berger P., Lepperdinger G., Grubeck-Loebenstein B. How sex and age affect immune responses, susceptibility to infections, and response to vaccination. Aging Cell. 2015;14(3):309–321. doi: 10.1111/acel.12326. - DOI - PMC - PubMed

[10] Giefing-Kröll C., Berger P., Lepperdinger G., Grubeck-Loebenstein B. How sex and age affect immune responses, susceptibility to infections, and response to vaccination. Aging Cell. 2015;14(3):309–321. doi: 10.1111/acel.12326. - DOI - PMC - PubMed

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Bioavailable testosterone level is associated with COVID-19 severity in female: A sex-stratified Mendelian randomization study

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Bioavailable testosterone level is associated with COVID-19 severity in female: A sex-stratified Mendelian randomization study

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