Epoxides: Developability as active pharmaceutical ingredients and biochemical probes

Baljit Kaur; Palwinder Singh

doi:10.1016/j.bioorg.2022.105862

Epoxides: Developability as active pharmaceutical ingredients and biochemical probes

Bioorg Chem. 2022 Aug:125:105862. doi: 10.1016/j.bioorg.2022.105862. Epub 2022 May 11.

Authors

Baljit Kaur¹, Palwinder Singh²

Affiliations

¹ Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
² Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: palwinder.chem@gndu.ac.in.

PMID: 35584607
DOI: 10.1016/j.bioorg.2022.105862

Abstract

Epoxide functional group is a part of several natural as well as synthetic compounds. Irrespective of the role of epoxide group in drug efficacy and the use of epoxide compounds as tool molecules, uncertainty prevails over concerns associated with the reactivity of this functional group. Herein, we compile information about epoxide-based medicinal compounds and biochemical probes and look into the related advantages and challenges of the epoxide functional group. As a whole, this study is focussed on analyzing the strategies which have been adopted for the successful development of epoxide-based compounds within drug discovery programs.

Keywords: Biochemistry and pharmacology of epoxide-based drugs; Epoxide functional group; Epoxide in metabolic pathways; Epoxide-based drugs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Epoxide Hydrolases*
Epoxy Compounds*
Pharmaceutical Preparations

Substances

Epoxy Compounds
Pharmaceutical Preparations
Epoxide Hydrolases