A Review on Bioactive Compounds from Marine-Derived Chaetomium Species

J Microbiol Biotechnol. 2022 May 28;32(5):541-550. doi: 10.4014/jmb.2201.01007.


Filamentous marine fungi have proven to be a plentiful source of new natural products. Chaetomium, a widely distributed fungal genus in the marine environment, has gained much interest within the scientific community. In the last 20 years, many potential secondary metabolites have been detected from marine-derived Chaetomium. In this review, we attempt to provide a comprehensive summary of the natural products produced by marine-derived Chaetomium species. A total of 122 secondary metabolites that were described from 2001 to 2021 are covered. The structural diversity of the compounds, along with details of the sources and relevant biological properties are also provided, while the relationships between structures and their bioactivities are discussed. It is our expectation that this review will be of benefit to drug development and innovation.

Keywords: Chaetomium; biological activity; secondary metabolite; structural diversity.

Publication types

  • Review

MeSH terms

  • Biological Products* / chemistry
  • Chaetomium* / chemistry
  • Chaetomium* / metabolism
  • Drug Development


  • Biological Products