Decreased Expressions of CK1α and PTEN in Sinonasal Inverted Papilloma

Appl Immunohistochem Mol Morphol. 2022 Jul 1;30(6):469-475. doi: 10.1097/PAI.0000000000001034. Epub 2022 May 17.


To investigate the diagnostic value of casein kinase 1α (CK1α) and phosphatase and tensin homolog (PTEN) in sinonasal inverted papilloma (SNIP), 42 control subjects and 56 SNIP patients were recruited in this study. Demographic and clinical characteristics, computerized tomography scans and endoscopic examinations were analyzed according to the Krouse staging system. Real-time quantitative-polymerase chain reaction and Western blotting were performed to detect CK1α and PTEN expression levels in different subgroups. Receiver operating characteristic and correlation analyses were conducted to assess their clinical significance in SNIP diagnosis. The expression levels of CK1α and PTEN were decreased in SNIP patients. Interestingly, the declined mRNA levels were consistent with the elevated Krouse staging and closely associated with the pathophysiological characteristics. Their expression levels also negatively correlated with neutrophil counts and positively correlated with lymphocyte counts in the blood of SNIP patients. This study suggests that CK1α and PTEN might be useful biomarkers for the occurrence and recurrence diagnosis of SNIP.

MeSH terms

  • Casein Kinase Ialpha*
  • Endoscopy
  • Humans
  • Nose Neoplasms* / diagnosis
  • Nose Neoplasms* / metabolism
  • PTEN Phosphohydrolase / genetics
  • Papilloma, Inverted* / genetics
  • Papilloma, Inverted* / metabolism
  • Paranasal Sinus Neoplasms* / metabolism


  • Casein Kinase Ialpha
  • PTEN Phosphohydrolase
  • PTEN protein, human