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, 274 (5673), 775-80

Molecular Basis of Base Substitution Hotspots in Escherichia Coli

Molecular Basis of Base Substitution Hotspots in Escherichia Coli

C Coulondre et al. Nature.

Abstract

In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.

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