Shared genetic architectures of subjective well-being in East Asian and European ancestry populations

Nat Hum Behav. 2022 Jul;6(7):1014-1026. doi: 10.1038/s41562-022-01343-5. Epub 2022 May 19.


Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Depressive Disorder, Major / genetics
  • Genome-Wide Association Study*
  • Humans
  • Mental Health*
  • Multifactorial Inheritance / genetics
  • Polymorphism, Single Nucleotide
  • White People / genetics