Fatty liver progression and carcinogenesis: Beware of pathogenic T cells

Petra Hirsova; Gregory J Gores

doi:10.1016/j.medj.2021.04.020

Fatty liver progression and carcinogenesis: Beware of pathogenic T cells

Med. 2021 May 14;2(5):453-455. doi: 10.1016/j.medj.2021.04.020.

Authors

Petra Hirsova¹, Gregory J Gores²

Affiliations

¹ Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
² Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address: gores.gregory@mayo.edu.

PMID: 35590223
DOI: 10.1016/j.medj.2021.04.020

Abstract

The pathogenesis of nonalcoholic steatohepatitis (NASH) and NASH-related liver cancer is incompletely understood. In the recent issue of Nature, two studies by Dudek et al. and Pfister et al. revealed the critical role of CD8 T cells in instigating liver damage and promoting liver cancer in NASH.¹^,².

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD8-Positive T-Lymphocytes / pathology
Carcinogenesis
Humans
Liver Neoplasms*
Lymphocyte Count
Non-alcoholic Fatty Liver Disease* / pathology

Abstract

Publication types

MeSH terms

Grants and funding