Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment

Brain Behav. 2022 Jun;12(6):e2608. doi: 10.1002/brb3.2608. Epub 2022 May 20.


Background: Long-term cognitive problems after neuroborreliosis treatment remain a subject of debate. We have previously shown that cognitive problems are not present in the acute phase of neuroborreliosis, although fatigue is common. The aim of this study was to re-assess the same patient cohort and evaluate long-term outcomes.

Methods: In this follow-up, we re-assessed 58 patients with well-characterized neuroborreliosis 12 months after completing treatment. The same protocol with eight subtests measuring attention and processing speed and the Fatigue Severity Scale (FSS) were used to compare the results from the acute phase to 12 months post treatment.

Results: We found no changes in attention or processing speed but a reduction in the level of fatigue (median score on FSS: 4.9 vs. 3.9, p < .001) from the acute phase to 12 months post treatment.

Conclusion: The patient group did not develop problems with attention or processing speed post treatment, while the level of fatigue decreased.

Keywords: Lyme; cognitive; fatigue; neuroborreliosis; prognosis.

MeSH terms

  • Cognition
  • Fatigue / etiology
  • Humans
  • Lyme Neuroborreliosis* / complications
  • Lyme Neuroborreliosis* / drug therapy
  • Nervous System Diseases*
  • Prospective Studies