Predicting speed of progression of lens opacification after pars plana vitrectomy with silicone oil

PLoS One. 2022 May 20;17(5):e0268377. doi: 10.1371/journal.pone.0268377. eCollection 2022.


Purpose: An increasing number of posterior segment disorders is routinely managed with pars plana vitrectomy (PPV). In older, phakic patients cataract formation is expected within the first two years after surgery. For younger patients its progression is individually fluctuating. This study uses an objective quantitative measurement for lens-status-monitoring after PPV with silicone oil to derive predictions for progression and severity of post-operative lens opacification evaluated in patients with rhegmatogenous retinal detachment (RRD).

Methods: Data acquisition was performed prospectively between March 2018 and March 2021. PentacamHR® Nucleus Staging mode (PNS) was used to objectively gather data about nuclear cataracts after PPV at different time points. Data was grouped into training and test sets for a mathematical prediction model. Via backward variable selection method a mathematical formula was set up by means of which predictions about lens densitometry (LD) can be calculated.

Results: 20 males [58.8%] and 14 females [41.2%] matched the inclusion criteria (mean age 50.6 years [23-75; ±12.3]). Average follow-up was 8.1 months (3,4-17.4; ±3.4). Mean baseline LD of the treated and fellow eye before surgery was 11.1% (7.7%-17.6%; ±2.0) and 11.2% (7.7%-14.8%; ±1.5), respectively. Predicted LD values by the model for five pre-selected patients closely match the observed data with an average deviation of 1.06%.

Conclusions: Using an objective parameter like LD delivered by the PentacamHR® PNS mode additionally to the patient's age allows us to make an individual prediction for any time after PPV with silicone oil due to RRD for all ages. The accuracy of the model was stronger influenced by baseline LD as cofactor in the equation than patient's age. The application for the prediction lens opacification [which can be accessed for free under the following link (] can help vitreoretinal surgeons for patient consultation on the possibility to combine PPV with cataract surgery.

MeSH terms

  • Aged
  • Cataract*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinal Detachment* / surgery
  • Retrospective Studies
  • Silicone Oils / adverse effects
  • Visual Acuity
  • Vitrectomy / adverse effects
  • Vitrectomy / methods


  • Silicone Oils

Grant support

The author(s) received no specific funding for this work.