The importance of timing in epilepsia partialis continua

Neurologia (Engl Ed). 2022 May;37(4):263-270. doi: 10.1016/j.nrleng.2019.03.020. Epub 2021 Apr 6.


Introduction: Timing is one of the most important modifiable prognostic factors in the management of status epilepticus. Epilepsia partialis continua (EPC) is a status epilepticus subtype of highly variable, occasionally prolonged, duration. The aim of this study was to analyse the relationship between EPC duration and outcomes.

Methods: We performed an observational prospective study of all patients with EPC admitted to our tertiary hospital between 1 September 2017 and 1 September 2018.

Results: The sample included 10 patients, of whom 9 were women; median age was 74 years. The most frequent aetiology was cerebrovascular disease (n = 6). EPC onset occurred outside the hospital in 5 patients, with a median time to hospital admission of 4 hours. The median time to treatment onset (TT) for all patients was 12.3 hours. The median time from treatment onset to EPC control (TC) was 30 hours; TC showed a strong positive correlation with TT (Spearman's rho = 0.88). Six patients presented hyperglycaemia at onset; this was positively correlated with TC (rho = 0.71). All 6 patients with hyperglycaemia presented a brain injury explaining the EPC episode.

Conclusions: Delays were observed in different phases of EPC management, which was related to longer duration of the episode. Glycaemia was also related to episode duration, probably acting as a triggering factor rather than as the aetiology.

Keywords: Duración; Duration; Epilepsia; Epilepsia parcial continua; Epilepsia partialis continua; Epilepsy; Estatus epiléptico; Retraso terapéutico; Status epilepticus; Tiempos; Timing; Treatment delay.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Electroencephalography
  • Epilepsia Partialis Continua* / etiology
  • Female
  • Humans
  • Hyperglycemia* / complications
  • Male
  • Prospective Studies
  • Status Epilepticus*