Diet in the Pathogenesis and Management of Crohn's Disease

Phillip Gu; Linda A Feagins

doi:10.1016/j.gtc.2021.12.008

Diet in the Pathogenesis and Management of Crohn's Disease

Gastroenterol Clin North Am. 2022 Jun;51(2):319-335. doi: 10.1016/j.gtc.2021.12.008. Epub 2022 Apr 22.

Authors

Phillip Gu¹, Linda A Feagins²

Affiliations

¹ Division of Digestive and Liver Diseases, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
² Department of Medicine, Center for Inflammatory Bowel Diseases, University of Texas at Austin, Dell Medical School, Health Discovery Building, Z0900 1601 Trinity Street, Building B, Austin, TX 78712, USA. Electronic address: Linda.Feagins@austin.utexas.edu.

PMID: 35595417
DOI: 10.1016/j.gtc.2021.12.008

Abstract

Crohn's disease (CD) is chronic immune-related disease of the gastrointestinal tract hypothesized to be caused by an interplay of genetic predisposition and environmental exposures. With the global incidence increasing, more patients are exploring dietary exposures to explain and treat CD. However, most patients report minimal nutritional education from their provider, and providers report few nutritional resources to help them educate patients. This highlights the previous deficit of literature describing the role and influence of diet in CD. To address this need, this article reviews available literature on the possible roles of diet in the pathogenesis, exacerbation, and treatment of CD.

Keywords: Crohn’s disease; Diet; Inflammatory bowel disease; Ulcerative colitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Colitis, Ulcerative* / therapy
Crohn Disease* / epidemiology
Crohn Disease* / etiology
Crohn Disease* / therapy
Diet / adverse effects
Genetic Predisposition to Disease
Humans
Incidence