Intestinal Cancer and Dysplasia in Crohn's Disease

Gastroenterol Clin North Am. 2022 Jun;51(2):369-379. doi: 10.1016/j.gtc.2021.12.011. Epub 2022 Apr 22.


Crohn's disease is associated with an increased risk of adenocarcinoma of the involved portions of the small bowel and colorectum and has similar risk factors to those described in ulcerative colitis, most significantly, extent of bowel involvement, PSC, and duration of unresected disease. Prevention strategies include risk stratification and secondary prevention with colonoscopic screening and surveillance to identify dysplasia or early-stage cancers, with surgery when needed. There is emerging information to suggest that control of inflammation may provide primary prevention of neoplasia, but further studies are required to test this strategy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colitis, Ulcerative* / pathology
  • Colonoscopy
  • Crohn Disease* / complications
  • Crohn Disease* / diagnosis
  • Crohn Disease* / pathology
  • Humans
  • Hyperplasia
  • Intestinal Neoplasms* / diagnosis
  • Intestinal Neoplasms* / etiology