Prenatal persistent left superior vena cava in low population: Not a benign vascular anomaly

Taiwan J Obstet Gynecol. 2022 May;61(3):459-463. doi: 10.1016/j.tjog.2022.03.011.


Objective: The aim of this study is to identify prenatally diagnosed cases of persistent left superior vena cava (PLSVC) in our clinic, to evaluate the associated structural and chromosomal results, and to review their outcome.

Materials and methods: During a four-year period, patients with fetal PLSVC were detected by echocardiography. We reviewed medical records of these affected pregnancies, including maternal demographics, sonographic findings, chromosomal microarray results and pregnancy outcomes.

Results: There were a total of 140 cases of fetal PLSVC. Eighty-nine fetuses (63.6%) had associated structural anomalies, while the remaining 51 fetuses (36.3%) had PLSVC as an isolated finding. In the non-isolated cases, cardiac anomalies were present in 72 fetuses (80.9%), and extracardiac abnormalities in 45 fetuses (50.6%). Among the 89 cases with non-isolated PLSVC, 12 cases had chromosomal abnormalities including 5 cases of aneuploidies. Among the 51 cases with isolated PLSVC, one pregnancy of chromosomal microduplication was detected.

Conclusion: Isolated PLSVC is a benign vascular anomaly in low risk population. However, the information about background risk of identifying an abnormal clinically significant CMA result should be conveyed to all pregnant women when they consults this vascular variation.

Keywords: Cardiac anomaly; Chromosomal microarray analysis; Persistent left superior vena cava; Prenatal diagnosis; Ultrasound.

MeSH terms

  • Female
  • Fetus / abnormalities
  • Humans
  • Persistent Left Superior Vena Cava*
  • Pregnancy
  • Ultrasonography, Prenatal / methods
  • Vascular Malformations* / diagnostic imaging
  • Vascular Malformations* / genetics
  • Vena Cava, Superior / diagnostic imaging
  • Vitamins


  • Vitamins