Acute Pericarditis: Update

Curr Cardiol Rep. 2022 Aug;24(8):905-913. doi: 10.1007/s11886-022-01710-8. Epub 2022 May 20.


Purpose of review: Since 2015, when ESC guidelines for the diagnosis and management of pericardial diseases were published, ongoing research has enhanced the current state of knowledge on acute pericarditis. This review is an update on the latest developments in this field.

Recent findings: In recurrent acute pericarditis, autoinflammation has been included among causative mechanisms restricting the vague diagnoses of "idiopathic" pericarditis. Cardiac magnetic resonance that detects ongoing pericardial inflammation may guide treatment in difficult-to-treat patients. Development of risk scores may assist identification of patients at high risk for complicated pericarditis, who should be closely monitored and aggressively treated. Treatment with IL-1 inhibitors has been proven efficacious in recurrent forms with a good safety profile. Finally, acute pericarditis has recently attracted great interest as it has been reported among side effects post COVID-19 vaccination and may also complicate SARS-CoV-2 infection. Recent advancements in acute pericarditis have contributed to a better understanding of the disease allowing a tailored to the individual patient approach. However, there are still unsolved questions that require further research.

Keywords: Acute pericarditis; Novel treatments; Outcome; Pathophysiology; Recurrent pericarditis.

Publication types

  • Review

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • Pericarditis* / diagnosis
  • Pericarditis* / drug therapy
  • Pericardium
  • SARS-CoV-2


  • COVID-19 Vaccines