Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008

J Gen Appl Microbiol. 2022 Nov 22;68(4):200-206. doi: 10.2323/jgam.2022.03.002. Epub 2022 May 20.

Abstract

A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds.

Keywords: Hypomyces pseudocorticiicola; antifungal activity; hakuhybotric acid.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Hypocreales*
  • Microbial Sensitivity Tests
  • Polyketides* / pharmacology

Substances

  • Antifungal Agents
  • F2928-1
  • Polyketides

Supplementary concepts

  • Hypomyces pseudocorticiicola