Background: Accelerated by the coronavirus disease 2019 (Covid-19) pandemic, major and lasting changes are occuring in healthcare structures, impacting people's experiences and value creation in all aspects of their lives. Information systems (IS) research can support analysing and anticipating resulting effects.
Aim: The purpose of this study is to examine in what areas health information systems (HIS) researchers can assess changes in healthcare structures and, thus, be prepared to shape future developments.
Method: A hermeneutic framework is applied to conduct a literature review and to identify the contributions that IS research makes in analysing and advancing the healthcare industry.
Results: We draw an complexity theory by borrowing the concept of 'zooming-in and out', which provides us with a overview of the current, broad body of research in the HIS field. As a result of analysing almost 500 papers, we discovered various shortcomings of current HIS research.
Contribution: We derive future pathways and develop a research agenda that realigns IS research with the transformation of the healthcare industry already under way.
Supplementary information: The online version contains supplementary material available at 10.1007/s12525-021-00484-1.
Keywords: Health information systems research; Healthcare; Research agenda.
© The Author(s) 2021, corrected publication 2021.