A case of restless legs syndrome after BNT162b2 mRNA COVID-19 vaccination

Neurol Clin Neurosci. 2022 May;10(3):178-180. doi: 10.1111/ncn3.12594. Epub 2022 Mar 26.


Restless legs syndrome (RLS) can be secondary to several disorders. We present an 87-year-old woman who developed RLS 2 days after the first injection of BNT162b2 mRNA coronavirus disease 2019 vaccine. The symptoms of RLS tended to improve and eventually resolved with the administration of gabapentin.

Keywords: BNT162b2 mRNA vaccination COVID‐19; COVID‐19; restless legs syndrome; sleep‐related movement disorder.

Publication types

  • Case Reports