Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer

Front Cell Dev Biol. 2022 May 4;10:886191. doi: 10.3389/fcell.2022.886191. eCollection 2022.


Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.

Keywords: exosome; gastrointestinal cancer; lncRNAs; pathogenesis; treatment.

Publication types

  • Review