Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

Eur Respir J. 2022 Jun 16;59(6):2102373. doi: 10.1183/13993003.02373-2021. Print 2022 Jun.


Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cysts*
  • Humans
  • Idiopathic Pulmonary Fibrosis* / genetics
  • Lung
  • Lung Diseases* / genetics
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, Lysophosphatidic Acid* / genetics
  • Sequence Analysis, RNA
  • Single-Cell Analysis


  • GPR87 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid