Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Jonathan D Newman; Pamela S Douglas; Ilya Zhbannikov; Maros Ferencik; Borek Foldyna; Udo Hoffmann; Svati H Shah; Geoffrey S Ginsburg; Michael T Lu; Deepak Voora

doi:10.1016/j.ahj.2022.05.012

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Am Heart J. 2022 Oct:252:12-15. doi: 10.1016/j.ahj.2022.05.012. Epub 2022 May 21.

Affiliations

¹ The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016. Electronic address: Jonathan.Newman@nyumc.org.
² The Leon H Charney Division of Cardiology, The Center for the Prevention of Cardiovascular Disease, New York, NY 10016.

Abstract

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

Publication types

Letter
Multicenter Study
Research Support, N.I.H., Extramural

MeSH terms

Chest Pain / diagnosis
Chest Pain / etiology
Computed Tomography Angiography
Coronary Angiography / methods
Coronary Artery Disease* / diagnostic imaging
Coronary Artery Disease* / genetics
Humans
Phenotype
Predictive Value of Tests
Prospective Studies
Risk Assessment
Risk Factors

Grants and funding

R56 HL155528/HL/NHLBI NIH HHS/United States