The effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study

BMC Res Notes. 2022 May 23;15(1):189. doi: 10.1186/s13104-022-06074-4.


Objective: The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine.

Results: Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group over 2-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin, and Visfatin were measured using the ELISA method. In addition, the headache attack frequencies, severity, and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). In the case of resistin and visfatin, nano-curcumin supplementation exerted no statistically significant changes in serum levels (P > 0.05). Nano-curcumin also significantly reduced the attack frequencies, severity, and duration of headaches (P < 0.05). These findings indicate that targeting curcumin can be a promising approach to migraine management. However, further comprehensive human trials are needed to confirm these findings.

Trial registration: This study was registered in the Iranian Registry of Clinical Trials (IRCT) with ID number: IRCT20160626028637N2 on the date 2020-07-10.

Keywords: MCP-1; Migraine; Nano-curcumin; Resistin; Serum levels; Visfatin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adipokines
  • Curcumin* / therapeutic use
  • Dietary Supplements
  • Double-Blind Method
  • Humans
  • Iran
  • Migraine Disorders* / complications
  • Migraine Disorders* / drug therapy
  • Nicotinamide Phosphoribosyltransferase / therapeutic use
  • Obesity / complications
  • Obesity / drug therapy
  • Overweight / complications
  • Overweight / drug therapy
  • Resistin


  • Adipokines
  • Resistin
  • Nicotinamide Phosphoribosyltransferase
  • Curcumin