Mining cell-cell signaling in single-cell transcriptomics atlases

Curr Opin Cell Biol. 2022 Jun;76:102101. doi: 10.1016/ Epub 2022 May 21.


Recent advances in single-cell RNA sequencing (scRNA-seq) techniques lead to an explosion of single-cell atlases from diverse biological contexts. The information of cell-cell signaling events, which underlie multicellular organism function, is embedded in these atlases. Here, we review current strategies of mining cell-cell signaling events from single-cell transcriptomics datasets and highlight examples where functions of predicted cell-cell signaling events from single-cell atlases are further pursued to yield new insights into biological processes.

Publication types

  • Review

MeSH terms

  • Cell Communication
  • Signal Transduction
  • Single-Cell Analysis*
  • Transcriptome*