Fibrin Sealants: Challenges and Solutions

ACS Biomater Sci Eng. 2022 Jun 13;8(6):2220-2231. doi: 10.1021/acsbiomaterials.1c01437. Epub 2022 May 24.


Intraoperative bleeding and postoperative bleeding are major surgical complications. Tissue sealants, hemostats, and adhesives provide the armamentarium for establishing hemostatic balance, including the tissue sealant fibrin. Fibrin sealants combine advantages including instantaneous effect, biocompatibility, and biodegradability. However, several challenges remain. This review summarizes current fibrin product generations and highlights new trends and potential strategies for future improvement.

Keywords: fibrin; fibrinogen; glue; hemostasis; medical device; sealant; surgery.

Publication types

  • Review

MeSH terms

  • Fibrin
  • Fibrin Tissue Adhesive* / therapeutic use
  • Hemostasis, Surgical
  • Hemostatics* / pharmacology
  • Hemostatics* / therapeutic use


  • Fibrin Tissue Adhesive
  • Hemostatics
  • Fibrin