Increased receptor affinity of SARS-CoV-2: a new immune escape mechanism

Martin F Bachmann; Mona O Mohsen; Daniel E Speiser

doi:10.1038/s41541-022-00479-9

Increased receptor affinity of SARS-CoV-2: a new immune escape mechanism

NPJ Vaccines. 2022 May 25;7(1):56. doi: 10.1038/s41541-022-00479-9.

Authors

Martin F Bachmann¹, Mona O Mohsen², Daniel E Speiser³

Affiliations

¹ University Hospital and University of Bern, Bern, Switzerland. martin.bachmann@dbmr.unibe.ch.
² University Hospital and University of Bern, Bern, Switzerland.
³ University Hospital and University of Bern, Bern, Switzerland. daniel.speiser@unil.ch.

Abstract

‘Affinity escape’: Novel SARS-CoV-2 variants may escape immunity by raising the RBD-ACE2 affinity high enough to outcompete the avidity of neutralizing antibodies.