Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast

Nature. 1987 Apr 2-8;326(6112):466-70. doi: 10.1038/326466a0.


The two strands of the DNA molecule are complementary but not identical. Hence, upon semiconservative replication, different parental DNA strands are segregated to daughter cells. A molecular analysis suggests that the process of fission yeast mating-type interconversion uses asymmetry of the DNA strands to generate a regular lineage of cellular differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Cycle
  • DNA Replication
  • DNA, Fungal / genetics*
  • Saccharomycetales / genetics*
  • Schizosaccharomyces / cytology
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces / growth & development


  • DNA, Fungal