Intracranial aneurysms and heredity

Neurosurgery. 1987 Feb;20(2):236-9. doi: 10.1227/00006123-198702000-00006.

Abstract

The occurrence of intracranial aneurysms (IAs) in the families of 579 consecutive patients with subarachnoid hemorrhage (SAH), of whom 485 had verified IAs, was studied retrospectively. IAs occurred in the families of 6.7% of the IA patients, but only 0.4% of their siblings had IAs. However, there were differences between the familial and nonfamilial IA patients, indicating that the familial patients are a specific small subpopulation of IA patients. The familial patients were younger, often had multiple aneurysms, and had aneurysms frequently located on arteries other than those in the nonfamilial group.

MeSH terms

  • Adult
  • Age Factors
  • Female
  • Humans
  • Hypertension / complications
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / genetics*
  • Intracranial Aneurysm / pathology
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk
  • Sex Factors
  • Subarachnoid Hemorrhage / complications
  • Surveys and Questionnaires