Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)-H bonds

Nat Commun. 2022 May 26;13(1):2938. doi: 10.1038/s41467-022-30367-8.


Hydroarylation of alkynes with unactivated C(sp2)-H bonds via chelated C-H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp2)-H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni-Al bimetallic catalyst to enable β-C-H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.