Chagas disease in Oklahoma

Am J Med Sci. 2022 Nov;364(5):521-528. doi: 10.1016/j.amjms.2022.03.018. Epub 2022 May 24.


Chagas disease, caused by infection with the protozoan Trypanosoma cruzi, is one of the leading public health problems in the Western Hemisphere. The parasite is mainly transmitted by contact with infected insect vectors but other forms of transmission are important in endemic areas. In the United States, while the disease is largely restricted to immigrants from endemic countries in Latin America, there is some risk of local acquisition. T. cruzi circulates in a sylvatic cycle between mammals and local triatomine insects in the southern half of the country, where human residents may be at risk for incidental infection. There are several reported cases of locally-acquired Chagas disease in the United States, but there is a paucity of information in Oklahoma. We present a brief summary of the available data of Chagas disease in Oklahoma to raise awareness and serve as a foundation for future research.

Keywords: Benznidazole; Chagas; Nifurtimox; Oklahoma; Trypanosoma.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chagas Disease* / epidemiology
  • Chagas Disease* / parasitology
  • Humans
  • Insect Vectors / parasitology
  • Mammals
  • Oklahoma / epidemiology
  • Trypanosoma cruzi*
  • United States