Identifying novel biomarkers with TMS-EEG - Methodological possibilities and challenges

Elisa Kallioniemi; Zafiris J Daskalakis

doi:10.1016/j.jneumeth.2022.109631

Identifying novel biomarkers with TMS-EEG - Methodological possibilities and challenges

J Neurosci Methods. 2022 Jul 15:377:109631. doi: 10.1016/j.jneumeth.2022.109631. Epub 2022 May 24.

Authors

Elisa Kallioniemi¹, Zafiris J Daskalakis²

Affiliations

¹ Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, United States. Electronic address: elisa.kallioniemi@gmail.com.
² Department of Psychiatry, University of California, San Diego Health, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address: zdaskalakis@health.ucsd.edu.

PMID: 35623474
DOI: 10.1016/j.jneumeth.2022.109631

Abstract

Biomarkers are essential for understanding the underlying pathologies in brain disorders and for developing effective treatments. Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an emerging neurophysiological tool that can be used for biomarker development. This method can identify biomarkers associated with the function and dynamics of the inhibitory and excitatory neurotransmitter systems and effective connectivity between brain areas. In this review, we outline the current state of the TMS-EEG biomarker field by summarizing the existing protocols and the possibilities and challenges associated with this methodology.

Keywords: Biomarker; Electroencephalography; Excitation; Inhibition; TMS-EEG; Transcranial magnetic stimulation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Electroencephalography* / methods
Transcranial Magnetic Stimulation* / methods
Treatment Outcome

Substances

Biomarkers