A community approach to the cancer-variant-interpretation bottleneck

Nat Cancer. 2022 May;3(5):522-525. doi: 10.1038/s43018-022-00379-w.


As guidelines, therapies, and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public domain, crowd-sourced, and adaptable knowledgebase of evidence for the Clinical Interpretation of Variants in Cancer, designed to reduce barriers to knowledge sharing and alleviate the variant interpretation bottleneck.

MeSH terms

  • Genetic Variation
  • Humans
  • Neoplasms* / diagnosis