Celiac Disease and Thrombotic Events: Systematic Review of Published Cases

Nutrients. 2022 May 23;14(10):2162. doi: 10.3390/nu14102162.


Extraintestinal manifestations of celiac disease (CD) should be considered, even in patients without typical intestinal symptoms. The aim of our study is to examine the literature regarding the occurrence of thrombotic events in CD, and to synthesize the data from case reports and case series. A systematic review of the literature was conducted by searching the Pub-Med/MEDLINE database, from the date of database inception to January 2022, to identify published cases and case series on this topic, in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 55 cases were included in the study. The majority of patients were previously healthy individuals, with no comorbidities. In less than one-third of the cases (30.91%), the diagnosis of CD was established before the onset of thrombosis, while in the remaining cases (34.54%), thrombosis preceded the diagnosis or was diagnosed concomitantly with CD. The most common sites for thrombosis occurrence were hepatic veins (30.91%), while thrombosis of cerebral blood vessels, deep venous thrombosis of lower extremities, and pulmonary thromboembolism were less frequent. Thrombosis was most commonly isolated to one site only (78.18%). In 69.09% of cases (n = 38), some form of anticoagulation, along with a gluten-free diet, was initiated.

Keywords: celiac disease; extraintestinal celiac manifestations; gluten-sensitive enteropathy; hypercoagulability; thromboembolism; thrombosis; thrombotic events.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Celiac Disease* / complications
  • Celiac Disease* / epidemiology
  • Humans
  • Lower Extremity
  • Publications
  • Pulmonary Embolism*
  • Thrombosis* / epidemiology
  • Thrombosis* / etiology

Grants and funding

This research received no external funding.