Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article

JNMA J Nepal Med Assoc. 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324.


Neonatal sepsis is a serious condition in which the pathogens infiltrate the bloodstream, multiply and produce toxins causing deleterious effects to the health of neonates. It is divided into two types on the basis of the time of onset. Early onset sepsis occurs within 72 hours of birth and late onset sepsis begins after 72 hours of delivery. Neonatal sepsis continues to be a common and significant health care burden, especially in very low birth weight infants (with birthweight less than 1500 grams). Though intrapartum antibiotic prophylaxis has decreased the incidence of early-onset group B streptococcal infection dramatically, it still remains a major cause of neonatal sepsis. As the signs and symptoms of neonatal sepsis are nonspecific, early diagnosis and prompt treatment remain a challenge.

Keywords: cytokines; immunoglobulin; neonatal sepsis; procalcitonin.

Publication types

  • Review

MeSH terms

  • Antibiotic Prophylaxis
  • Birth Weight
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Very Low Birth Weight
  • Neonatal Sepsis* / diagnosis
  • Neonatal Sepsis* / therapy
  • Sepsis* / drug therapy
  • Sepsis* / therapy