Isolation of a new steroid from phytochemical investigation on Caralluma lasiantha

Malladi Sireesha; Venkata Nadh Ratnakaram; Kothamasu Suresh Babu; Sri Vedavyasa Radhakrishnan

doi:10.1080/10286020.2022.2080671

Isolation of a new steroid from phytochemical investigation on Caralluma lasiantha

J Asian Nat Prod Res. 2022 May 29:1-7. doi: 10.1080/10286020.2022.2080671. Online ahead of print.

Authors

Malladi Sireesha¹, Venkata Nadh Ratnakaram², Kothamasu Suresh Babu³, Sri Vedavyasa Radhakrishnan⁴

Affiliations

¹ Division of Chemistry, Department of Science and Humanities, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Vadlamudi, Guntur, Andhra Pradesh 522213, India.
² Industrial Chemical Product Development and Analysis Centre, GITAM Deemed to be University, Bengaluru Campus, Karnataka 561203, India.
³ Department of Chemistry, Marri Laxman Reddy Institute of Technology and Management, Dindigal, Hyderabad 500043, India.
⁴ Natural Products Laboratory, Organic Division-1, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.

PMID: 35635100
DOI: 10.1080/10286020.2022.2080671

Abstract

A new steroid (acylated C₂₁ pregnane steroid) was isolated from chloroform extract in phytochemical screening of Caralluma lasiantha. The isolated compound is found to be 3β-hydroxy-14β-(6'- carboxyphenyl)propionyloxypregn-5-en-20-one based on spectroscopic studies (IR, ¹H NMR, ¹³C NMR, DEPT, COSY, HSQC, HMBC and ESI-MS). The isolated new steroid was tested against four bacterial strains and the activity was related to the structure of the molecule.

Keywords: Asclepiadaceae; C31 pregnane steroid; Caralluma lasiantha; Indian traditional medicine; chloroform extract; phytochemical screening.