Small molecules in the big picture of gut microbiome-host cross-talk

Yue Ma; Xiaolin Liu; Jun Wang

doi:10.1016/j.ebiom.2022.104085

Small molecules in the big picture of gut microbiome-host cross-talk

EBioMedicine. 2022 Jul:81:104085. doi: 10.1016/j.ebiom.2022.104085. Epub 2022 May 27.

Authors

Yue Ma¹, Xiaolin Liu¹, Jun Wang²

Affiliations

¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: junwang@im.ac.cn.

Abstract

Research on the gut microbiome and related diseases is rapidly growing with the development of sequencing technologies. An increasing number of studies offer new perspectives on disease development or treatment. Among these, the mechanisms of gut microbial metabolite-mediated effects merit better understanding. In this review, we first summarize the shifts in gut microbial metabolites within complex diseases, in which metabolites have correlational and occasionally causal effects on diseases and discuss the reported mechanisms. We further investigate the interactions between gut microbes and drugs, providing insights for precision medication as well as limitations of current research. Finally, we provide new research directions and research strategies for the development of drugs from gut microbial metabolites. FUNDING STATEMENT: None.

Keywords: Drug-microbiome interaction; Gut microbial metabolites; Health and diseases; Host-microbiome cross-talk.

Publication types

Review

MeSH terms

Gastrointestinal Microbiome*
Humans