Persistent Orthostatic Hypotension in a Patient With Acromegaly: Resolution With Transsphenoidal Hypophysectomy

Cureus. 2022 Apr 24;14(4):e24436. doi: 10.7759/cureus.24436. eCollection 2022 Apr.


Acromegaly is a rare condition characterized by excessive secretion of growth hormone from a pituitary tumor. It can affect multiple systems and can be fatal with cardiac dysfunction being the most common cause of death in these patients. Autonomic dysfunction is a less studied subject in patients with acromegaly, and the exact pathophysiology is still unclear. Here we present a case of a patient with persistent orthostatic hypotension, who was found to have acromegaly and pituitary adenoma upon further evaluation. Her orthostatic symptoms failed to improve with conservative measures and medical management, but unexpectedly resolved after transsphenoidal hypophysectomy was performed.

Keywords: acromegaly and surgery; adrenal insufficiency; neurogenic orthostatic hypotension; pituitary and diabetes; trans-sphenoidal resection.

Publication types

  • Case Reports