Cohort Profile: The LIFE-Adult-Study

doi:10.1093/ije/dyac114

. 2023 Feb 8;52(1):e66-e79.

doi: 10.1093/ije/dyac114.

Cohort Profile: The LIFE-Adult-Study

Christoph Engel^{1

2}, Kerstin Wirkner^{1

2}, Samira Zeynalova^{1

2}, Ronny Baber^{2

3}, Hans Binder⁴, Uta Ceglarek^{2

3}, Cornelia Enzenbach^{1

2}, Michael Fuchs^{2

5}, Andreas Hagendorff⁶, Sylvia Henger^{1

2}, Andreas Hinz⁷, Franziska G Rauscher^{1

2}, Matthias Reusche^{1

2}, Steffi G Riedel-Heller⁸, Susanne Röhr^{8

9}, Julia Sacher^{10

11}, Christian Sander^{2

12}, Matthias L Schroeter^{10

11}, Attila Tarnok^{1

13}, Regina Treudler^{14

15}, Arno Villringer^{10

11}, Rolf Wachter¹⁶, A Veronica Witte^{10

11}, Joachim Thiery^{2

3}, Markus Scholz^{1

2}, Markus Loeffler^{1

2}; LIFE-Adult-Study working group

Collaborators, Affiliations

Collaborators

LIFE-Adult-Study working group:
Peter Ahnert, Yoon Ju Bae, Daniel Baier, Martin Berg, Thomas Berger, Frank Beutner, Frauke Beyer, Elmar Brähler, Petra Büttner, Ralph Burkhardt, Julia Dittrich, Ezgi Dogan-Sander, Tobias Elze, Michael Gaebler, Stephan Gielen, Heide Glaesmer, Ulrich Hegerl, Tilman Hensch, Anja Hilbert, Felix S Hussenoeder, Daniela Husser, Philippe Jawinski, Lasse Jost, Jan Keil, Shahrzad Kharabian Masouleh, Alexander Kiel, Toralf Kirsten, Michael Kluge, Rüya-Daniela Kocalevent, Jelena Kornej, Andreas Kühnapfel, Deniz Kumral, Jana Kynast, Leonie Lampe, Franziskus Liem, Antje Löffler, Henry Loeffler-Wirth, Noah Lorenz, Tobias Luck, Daniel S Margulies, Mila Massué, Susanne Melzer, Jeffrey Netto, Matthias Nüchter, Maryna Polyakova, Janne Pott, Madlen Reinicke, Nigar Reyes, Francisca S Rodriguez, H Lina Schaare, Peter Schönknecht, Jan C Simon, Janek Spada, Ronald Speer, Daniela Stanikova, Andrej Teren, Christine Ulke, Gunnar Wichmann, Barbara Wicklein, Anja Willenberg, Dirk Alexander Wittekind, Maryam Yahiaoui-Doktor, Silke Zachariae, Rui Zhang, Rachel G Zsido, Andrea E Zuelke

Affiliations

¹ Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.
² Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany.
³ Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany.
⁴ Interdisciplinary Centre for Bioinformatics, Leipzig University, Leipzig, Germany.
⁵ Division Otolaryngology, Head and Neck Surgery, Phoniatrics and Audiology, University of Leipzig Medical Center, Leipzig, Germany.
⁶ Department of Cardiology, University of Leipzig Medical Center, Leipzig, Germany.
⁷ Department of Medical Psychology and Medical Sociology, Leipzig University, Leipzig, Germany.
⁸ Institute of Social Medicine, Occupational Medicine and Public Health (ISAP), Leipzig University, Leipzig, Germany.
⁹ Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
¹⁰ Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.
¹¹ Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
¹² Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
¹³ Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
¹⁴ Department of Dermatology, Venerology and Allergology, University of Leipzig Medical Center, Leipzig, Germany.
¹⁵ Leipzig Interdisciplinary Allergy Center (LICA)-Comprehensive Allergy Center, University of Leipzig Medical Center, Leipzig, Germany.
¹⁶ Clinic and Policlinic for Cardiology, University of Leipzig Medical Center, Leipzig, Germany.

PMID: 35640047
PMCID: PMC9908058
DOI: 10.1093/ije/dyac114

Cohort Profile: The LIFE-Adult-Study

Christoph Engel et al. Int J Epidemiol. 2023.

. 2023 Feb 8;52(1):e66-e79.

doi: 10.1093/ije/dyac114.

Authors

Collaborators

LIFE-Adult-Study working group:
Peter Ahnert, Yoon Ju Bae, Daniel Baier, Martin Berg, Thomas Berger, Frank Beutner, Frauke Beyer, Elmar Brähler, Petra Büttner, Ralph Burkhardt, Julia Dittrich, Ezgi Dogan-Sander, Tobias Elze, Michael Gaebler, Stephan Gielen, Heide Glaesmer, Ulrich Hegerl, Tilman Hensch, Anja Hilbert, Felix S Hussenoeder, Daniela Husser, Philippe Jawinski, Lasse Jost, Jan Keil, Shahrzad Kharabian Masouleh, Alexander Kiel, Toralf Kirsten, Michael Kluge, Rüya-Daniela Kocalevent, Jelena Kornej, Andreas Kühnapfel, Deniz Kumral, Jana Kynast, Leonie Lampe, Franziskus Liem, Antje Löffler, Henry Loeffler-Wirth, Noah Lorenz, Tobias Luck, Daniel S Margulies, Mila Massué, Susanne Melzer, Jeffrey Netto, Matthias Nüchter, Maryna Polyakova, Janne Pott, Madlen Reinicke, Nigar Reyes, Francisca S Rodriguez, H Lina Schaare, Peter Schönknecht, Jan C Simon, Janek Spada, Ronald Speer, Daniela Stanikova, Andrej Teren, Christine Ulke, Gunnar Wichmann, Barbara Wicklein, Anja Willenberg, Dirk Alexander Wittekind, Maryam Yahiaoui-Doktor, Silke Zachariae, Rui Zhang, Rachel G Zsido, Andrea E Zuelke

Affiliations

¹ Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.
² Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany.
³ Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany.
⁴ Interdisciplinary Centre for Bioinformatics, Leipzig University, Leipzig, Germany.
⁵ Division Otolaryngology, Head and Neck Surgery, Phoniatrics and Audiology, University of Leipzig Medical Center, Leipzig, Germany.
⁶ Department of Cardiology, University of Leipzig Medical Center, Leipzig, Germany.
⁷ Department of Medical Psychology and Medical Sociology, Leipzig University, Leipzig, Germany.
⁸ Institute of Social Medicine, Occupational Medicine and Public Health (ISAP), Leipzig University, Leipzig, Germany.
⁹ Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
¹⁰ Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.
¹¹ Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
¹² Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
¹³ Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.
¹⁴ Department of Dermatology, Venerology and Allergology, University of Leipzig Medical Center, Leipzig, Germany.
¹⁵ Leipzig Interdisciplinary Allergy Center (LICA)-Comprehensive Allergy Center, University of Leipzig Medical Center, Leipzig, Germany.
¹⁶ Clinic and Policlinic for Cardiology, University of Leipzig Medical Center, Leipzig, Germany.

PMID: 35640047
PMCID: PMC9908058
DOI: 10.1093/ije/dyac114

No abstract available

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Figures

**Figure 1**
Planned and achieved sample size (baseline recruitment)

See this image and copyright information in PMC

Cited by

The Association of Resilience with Mental Health in a Large Population-Based Sample (LIFE-Adult-Study).
Weitzel EC, Löbner M, Glaesmer H, Hinz A, Zeynalova S, Henger S, Engel C, Reyes N, Wirkner K, Löffler M, Riedel-Heller SG. Weitzel EC, et al. Int J Environ Res Public Health. 2022 Nov 29;19(23):15944. doi: 10.3390/ijerph192315944. Int J Environ Res Public Health. 2022. PMID: 36498017 Free PMC article.
Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study.
Lammer L, Beyer F, Luppa M, Sanders C, Baber R, Engel C, Wirkner K, Loffler M, Riedel-Heller SG, Villringer A, Witte AV. Lammer L, et al. Elife. 2023 Jun 20;12:e83660. doi: 10.7554/eLife.83660. Elife. 2023. PMID: 37337666 Free PMC article.
Genome-Wide Association Study Meta-Analysis Uncovers Novel Genetic Variants Associated with Olfactory Dysfunction.
Imtiaz MA, Melas K, Tin A, Talevi V, Chen H, Fornage M, Shrestha S, Gögele M, Emmert D, Pattaro C, Pramstaller P, Förster F, Horn K, Mosley TH, Fuchsberger C, Scholz M, Breteler MMB, Aziz NA. Imtiaz MA, et al. medRxiv [Preprint]. 2024 Aug 10:2024.08.09.24311665. doi: 10.1101/2024.08.09.24311665. medRxiv. 2024. PMID: 39148842 Free PMC article. Preprint.
Temporal stability of optimism and pessimism (LOT-R) over 6 years in the general population.
Hinz A, Friedrich M, Glaesmer H, Brendel B, Nesterko Y, Ernst J, Schroeter ML, Mehnert-Theuerkauf A. Hinz A, et al. Front Psychol. 2024 Jun 20;15:1379651. doi: 10.3389/fpsyg.2024.1379651. eCollection 2024. Front Psychol. 2024. PMID: 38966735 Free PMC article.
Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study.
Rauscher FG, Elze T, Francke M, Martinez-Perez ME, Li Y, Wirkner K, Tönjes A, Engel C, Thiery J, Blüher M, Stumvoll M, Kirsten T, Loeffler M, Ebert T, Wang M. Rauscher FG, et al. Diabetologia. 2024 May;67(5):928-939. doi: 10.1007/s00125-024-06093-9. Epub 2024 Mar 2. Diabetologia. 2024. PMID: 38431705 Free PMC article.

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References

1. Greiser KH, Kluttig A, Schumann B. et al. Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study. BMC Cardiovasc Disord 2005;5:33. - PMC - PubMed
1. Holle R, Happich M, Lowel H, Wichmann HE; MONICA/KORA Study Group. KORA--a research platform for population based health research. Gesundheitswesen 2005;67(Suppl 1):S19–25. - PubMed
1. Volzke H, Alte D, Schmidt CO. et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol 2011;40:294–307. - PubMed
1. Schmermund A, Mohlenkamp S, Stang A. et al. Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study: risk factors, evaluation of coronary calcium and lifestyle. Am Heart J 2002;144:212–18. - PubMed
1. Bellach BM, Knopf H, Thefeld W.. [The German Health Survey. 1997/98]. Gesundheitswesen 1998;60(Suppl 2):S59–68. - PubMed

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[1] Greiser KH, Kluttig A, Schumann B. et al. Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study. BMC Cardiovasc Disord 2005;5:33. - PMC - PubMed

[2] Greiser KH, Kluttig A, Schumann B. et al. Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study. BMC Cardiovasc Disord 2005;5:33. - PMC - PubMed

[3] Holle R, Happich M, Lowel H, Wichmann HE; MONICA/KORA Study Group. KORA--a research platform for population based health research. Gesundheitswesen 2005;67(Suppl 1):S19–25. - PubMed

[4] Holle R, Happich M, Lowel H, Wichmann HE; MONICA/KORA Study Group. KORA--a research platform for population based health research. Gesundheitswesen 2005;67(Suppl 1):S19–25. - PubMed

[5] Volzke H, Alte D, Schmidt CO. et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol 2011;40:294–307. - PubMed

[6] Volzke H, Alte D, Schmidt CO. et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol 2011;40:294–307. - PubMed

[7] Schmermund A, Mohlenkamp S, Stang A. et al. Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study: risk factors, evaluation of coronary calcium and lifestyle. Am Heart J 2002;144:212–18. - PubMed

[8] Schmermund A, Mohlenkamp S, Stang A. et al. Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study: risk factors, evaluation of coronary calcium and lifestyle. Am Heart J 2002;144:212–18. - PubMed

[9] Bellach BM, Knopf H, Thefeld W.. [The German Health Survey. 1997/98]. Gesundheitswesen 1998;60(Suppl 2):S59–68. - PubMed

[10] Bellach BM, Knopf H, Thefeld W.. [The German Health Survey. 1997/98]. Gesundheitswesen 1998;60(Suppl 2):S59–68. - PubMed

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Cohort Profile: The LIFE-Adult-Study

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Cohort Profile: The LIFE-Adult-Study

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