The possibility and feasibility of using the single-layer flat-coil-oscillator (SFCO) technology-based vibration and vibro-acoustic sensors in diagnostic devices and biomedical studies of the cardiovascular system are discussed in this paper. Using an example of recording pulse waves of left carotid artery and their analysis, the information content of the data recorded by these sensors in a number of cases is shown-assessment of age-related changes in the stiffness of the vascular wall, assessment of the dynamics of systolic volume, reflecting myocardial contractility, and rhythm disturbance (extra-systole and arrhythmia). These sensors are shown to be promising in recording heart sounds due to their high sensitivity. The possibility of assessing the dynamics of relaxation of the cardiovascular system after exercise (stress test) is shown. The advantages of using SFCO vibration and vibro-acoustic sensors are high sensitivity, ease of use, and no need to train specialists. These advantages open new perspectives for their implementation in mobile wearable "smart" devices for individual monitoring.