A rare MRI finding of NF-1: perineural arachnoidal gliomatosis

Childs Nerv Syst. 2022 Sep;38(9):1825-1828. doi: 10.1007/s00381-022-05563-y. Epub 2022 Jun 2.


Optic pathway gliomas are the most common central nervous system neoplasms in patients with neurofibromatosis type 1. Perineural arachnoidal gliomatosis is a rare and distinctive growth pattern of optic nerve glioma, in which the tumor infiltrates through the pia mater and pre-dominantly involves the subarachnoid space around the optic nerve. Here, we report an 8-year-old girl with perineural arachnoidal gliomatosis associated with neurofibromatosis type 1.

Keywords: Magnetic resonance imaging; Neurofibromatosis 1; Optic nerve glioma; Perineural arachnoidal gliomatosis.

Publication types

  • Case Reports

MeSH terms

  • Arachnoid / pathology
  • Child
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Neurofibromatosis 1* / complications
  • Neurofibromatosis 1* / diagnostic imaging
  • Neurofibromatosis 1* / pathology
  • Optic Nerve / pathology
  • Optic Nerve Glioma* / complications