New Views of Old Proteins: Clarifying the Enigmatic Proteome

Mol Cell Proteomics. 2022 Jul;21(7):100254. doi: 10.1016/j.mcpro.2022.100254. Epub 2022 May 30.


All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Keywords: biotechnology; proteins; proteomics; single-cell biology; single-molecule sequencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Proteome* / metabolism
  • Proteomics* / methods


  • Proteome