Transcatheter Closure of Atrial and Ventricular Septal Defects: JACC Focus Seminar

J Am Coll Cardiol. 2022 Jun 7;79(22):2247-2258. doi: 10.1016/j.jacc.2021.08.082.


The field of congenital interventional cardiology has experienced tremendous growth in recent years. Beginning with the development of early devices for transcatheter closure of septal defects in the 1970s and 1980s, such technologies have evolved to become a mainstay of treatment for many atrial septal defects (ASDs) and ventricular septal defects (VSDs). Percutaneous device closure is now the preferred approach for the majority of secundum ASDs. It is also a viable treatment option for selected VSDs, though limitations still exist. In this review, the authors describe the current state of transcatheter closure of ASDs and VSDs in children and adults, including patient selection, procedural approach, and outcomes. Potential areas for future evolution and innovation are also discussed.

Keywords: atrial septal defect; congenital heart disease; interventional cardiology; transcatheter device closure; ventricular septal defect.

Publication types

  • Review

MeSH terms

  • Adult
  • Cardiac Catheterization
  • Child
  • Foramen Ovale, Patent*
  • Heart Septal Defects, Ventricular* / surgery
  • Humans
  • Patient Selection