Translating Microbiome Research From and To the Clinic

Annu Rev Microbiol. 2022 Sep 8:76:435-460. doi: 10.1146/annurev-micro-041020-022206. Epub 2022 Jun 2.


Extensive research has elucidated the influence of the gut microbiota on human health and disease susceptibility and resistance. We review recent clinical and laboratory-based experimental studies associating the gut microbiota with certain human diseases. We also highlight ongoing translational advances that manipulate the gut microbiota to treat human diseases and discuss opportunities and challenges in translating microbiome research from and to the bedside.

Keywords: clinical trials; immune checkpoint inhibitor; infectious diseases; inflammatory bowel disease; microbiome; microbiota; translational research; transplantation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease*
  • Fecal Microbiota Transplantation
  • Gastrointestinal Microbiome*
  • Humans
  • Probiotics / therapeutic use
  • Therapeutics* / trends