Cerebellar atrophy in schizophrenia and affective disorder

Am J Psychiatry. 1987 Apr;144(4):465-7. doi: 10.1176/ajp.144.4.465.


The authors evaluated 108 patients with schizophrenia, 50 patients with affective disorder, and 74 age- and sex-matched control subjects by CAT scan for evidence of global cerebellar atrophy. No difference was found between control subjects and schizophrenic patients or between control subjects and patients with affective disorder. This study does not confirm previous reports linking cerebellar atrophy to schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Atrophy
  • Cerebellum / diagnostic imaging
  • Cerebellum / pathology*
  • Depressive Disorder / diagnosis*
  • Depressive Disorder / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Schizophrenia / diagnosis*
  • Schizophrenia / pathology
  • Tomography, X-Ray Computed