Hyperplastic polyposis of the colorectum and adenocarcinoma in a 24-year-old man

Am J Surg Pathol. 1987 Apr;11(4):323-7. doi: 10.1097/00000478-198704000-00010.


Hyperplastic polyps in the large intestine are considered common after the age of 40, devoid of neoplastic transformation capability, and have a well-defined histological picture. Nevertheless, there exists evidence that hyperplastic polyps can present with adenomatous areas, eventually leading to carcinoma. There has been a suggestion in certain cases that a transformational sequence might exist in the genesis of colorectal cancer: hyperplastic polyp-adenoma-adenocarcinoma. Adenocarcinoma resulting from a pure hyperplastic polyp has also been described. These data have generated reconsideration of the significance of hyperplastic polyps in relation to cancer. In this paper we present a 24-year-old man with adenocarcinoma of the colon who underwent a right hemicolectomy. Twenty-eight hyperplastic polyps were found in the surgical specimen. Two of these polyps had adenomatous areas. The patient died 18 months after the surgical resection.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / ultrastructure*
  • Adult
  • Carcinoembryonic Antigen / analysis
  • Colonic Neoplasms / ultrastructure*
  • Colonic Polyps / analysis
  • Colonic Polyps / ultrastructure*
  • Humans
  • Hyperplasia / pathology
  • Intestinal Polyps / analysis
  • Intestinal Polyps / ultrastructure*
  • Male
  • Neoplasms, Multiple Primary / pathology*
  • Rectal Neoplasms / analysis
  • Rectal Neoplasms / ultrastructure*


  • Carcinoembryonic Antigen