The circadian immune system

Sci Immunol. 2022 Jun 3;7(72):eabm2465. doi: 10.1126/sciimmunol.abm2465. Epub 2022 Jun 3.


The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified. These studies have revealed a highly complex picture of the interconnectivity of rhythmicity within immune cells with that of their environment. Here, we provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circadian Rhythm*
  • Immune System*