Nutritional Management of Short Bowel Syndrome

Clin Perinatol. 2022 Jun;49(2):557-572. doi: 10.1016/j.clp.2022.02.016. Epub 2022 Apr 21.


Short bowel syndrome (SBS) of infancy is a cause of prolonged morbidity with intolerance to enteral feeding, specialized nutritional needs, and partial/total dependence on parenteral nutrition. These infants can benefit from individualized nutritional strategies to support and enhance the process of intestinal adaptation. Early introduction of enteral feeds during the period of intestinal adaptation is crucial, even though the enteral feedings may need to be supplemented with an effective, safe, and nutritionally adequate parenteral nutritional regimen. Newer generation intravenous lipid emulsions can be effective in preventing and treating intestinal failure-associated liver disease. Prevention of infection(s), pharmaceutical interventions to enhance bowel motility and prevent/mitigate bacteria overgrowth, and specialized multidisciplinary care to minimize the injury to other organs such as the liver, kidneys, and the brain can assist in nutritional rehabilitation and lower the morbidity in SBS.

Keywords: Breast milk; Enteral nutrition; Growth; Intestinal failure; Nutrition; Parenteral nutrition; Short bowel syndrome; Short gut.

Publication types

  • Review

MeSH terms

  • Enteral Nutrition
  • Humans
  • Infant
  • Intestinal Diseases* / therapy
  • Intestines
  • Parenteral Nutrition
  • Short Bowel Syndrome* / therapy