Poly(m6A) tails stabilize transcripts

Guillaume Lavergne; Jean-Yves Roignant

doi:10.1016/j.molcel.2022.05.017

Poly(m⁶A) tails stabilize transcripts

Mol Cell. 2022 Jun 2;82(11):1979-1980. doi: 10.1016/j.molcel.2022.05.017.

Authors

Guillaume Lavergne¹, Jean-Yves Roignant²

Affiliations

¹ Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland.
² Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany. Electronic address: jean-yves.roignant@unil.ch.

PMID: 35659324
DOI: 10.1016/j.molcel.2022.05.017

Abstract

Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Mammals
Membrane Glycoproteins
Poly A / genetics
RNA, Messenger / genetics
Trypanosoma brucei brucei* / genetics
Variant Surface Glycoproteins, Trypanosoma* / genetics

Substances

Membrane Glycoproteins
RNA, Messenger
Variant Surface Glycoproteins, Trypanosoma
Poly A