Poly(m6A) tails stabilize transcripts

Mol Cell. 2022 Jun 2;82(11):1979-1980. doi: 10.1016/j.molcel.2022.05.017.


Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Mammals
  • Membrane Glycoproteins
  • Poly A / genetics
  • RNA, Messenger / genetics
  • Trypanosoma brucei brucei* / genetics
  • Variant Surface Glycoproteins, Trypanosoma* / genetics


  • Membrane Glycoproteins
  • RNA, Messenger
  • Variant Surface Glycoproteins, Trypanosoma
  • Poly A