New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Alcohol. 2022 Sep;103:1-7. doi: 10.1016/j.alcohol.2022.05.004. Epub 2022 Jun 1.


On November 19th, 2021, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at Loyola University Chicago Health Sciences Campus in Maywood, Illinois. The 2021 meeting focused on how alcohol misuse is linked to immune system derangements, leading to tissue and organ damage, and how this research can be translated into improving treatment of alcohol-related disease. This meeting was divided into three plenary sessions: the first session focused on how alcohol misuse affects different parts of the immune system, the second session presented research on mechanisms of organ damage from alcohol misuse, and the final session highlighted research on potential therapeutic targets for treating alcohol-mediated tissue damage. Diverse areas of alcohol research were covered during the meeting, from alcohol's effect on pulmonary systems and neuroinflammation to epigenetic changes, senescence markers, and microvesicle particles. These presentations yielded a thoughtful discussion on how the findings can lead to therapeutic treatments for people suffering from alcohol-related diseases.

Keywords: brain; cardiovascular disease; ethanol; inflammation; liver; lung; myopathy; pneumonia; skin; stem cell.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alcoholism* / genetics
  • Epigenesis, Genetic
  • Ethanol / adverse effects
  • Humans
  • Inflammation / genetics
  • Public Opinion


  • Ethanol